Research Area: Signal Transduction Pathways, GTPases and Cell Cycle Control.
The Oncogene Team studies the roles of cell signalling pathways in cancer.
A major focus is the function of the Ras and Rho families of small GTPases.
A particular focus in our current studies is the mechanisms of tumour cell
movement underpinning invasion and metastasis of cancer cells. We have
found that as well as a previously described Rac driven lamelliopdial form of
cell movement, there is an alternative mode of cell movement that unlike Rac
driven protrusive movement is absolutely dependent on Rho signalling to Rho kinase.
